New to GRIYO?
Start with a comprehensive visit so we can learn your history, priorities and goals.
Primary care for adults 18+
Healthcare that starts by listening.
Compassionate, comprehensive care for your whole health — with evening hours, Saturday visits and telehealth when you need flexibility.
Monday–Friday until 9 PMSaturday 9 AM–2 PM
“At GRIYO, we don't just treat conditions; we care for people.As your health fiduciary, we promise to provide the most up-to-date, evidence-based information so you can make empowered decisions about your health. Welcome home.”
Featured services
One trusted place for everyday health.
Preventive care, timely treatment and long-term support — built around your needs, your goals and your life.
Not sure where to begin?
Choose the kind of care that fits.
Whether this is your first visit or a follow-up, we’ll help you start in the right place.
Prefer in-person care?
Visit the San Antonio office for preventive, acute and ongoing care.
Need more flexibility?
Telehealth is available for appropriate follow-ups and non-emergency concerns.
Explore telehealth →Why choose GRIYO?
Care for your health. Respect for you.
We take time to understand what matters, explain your choices clearly and help you move forward with confidence.
A relationship built on listening.
Your concerns, routines and goals shape the conversation from the start. Every care plan begins with understanding you.
Clear explanations, shared decisions.
We explain your options in plain language so you can make informed choices and move forward with confidence.
Thoughtful support beyond today.
Preventive, acute and chronic care work together here, with follow-up that keeps your whole health in view.
We accept most insurances.
We work with most major insurance plans. Call the office and we’ll help you confirm your coverage before your visit.
No insurance, no problem.
Please call to make your appointment. Ask about our self-pay financing option.
Plan your visit
Care that fits the week you actually have.
New patients are welcome. Call or send an appointment request, and our office will help with the next step.
Office Hours
- Monday–Friday
- 9 AM–9 PM
- Saturday
- 9 AM–2 PM
- Sunday
- Closed
8223 Fredericksburg Rd, Suite 102
San Antonio, TX 78229
“Your reliable ally in wellness.”
GRIYO Primary Care is dedicated to compassionate, comprehensive healthcare for the San Antonio community. The practice serves adults ages 18 and older, in person and through telehealth for follow-ups and non-emergency concerns.
Our approach is personal: listen carefully, explain clearly and build a care plan with you. We want every patient to feel valued, understood and supported in taking charge of their health.
Personal by design
Careful attention at every step.
From the questions we ask to the way we explain next steps, GRIYO is designed to make every patient feel known, respected and supported.
Our values
What guides every visit.
Genuine compassion
Authentic empathy and kindness so patients feel valued and understood.
Respectful integrity
Transparency, honesty and high ethical standards throughout patient care.
Innovative excellence
Continuous learning and improvement in pursuit of high-quality care.
You-centered collaboration
A partnership that reflects each patient's needs and personal health journey.
Outreach
Proactive engagement and education that support a healthier community.
Our mission
Care with purpose.
Rooted in faith and integrity, GRIYO provides compassionate, patient-centered primary care that empowers people through education, personalized support and tailored treatment plans.
Our vision
A healthier community.
We envision people having the resources and support to reach optimal wellness through preventive care, strong relationships and thoughtful healthcare solutions.
Ready for care that feels personal?
Not sure which service you need?
Call (210) 993-3689Call the office and we'll help you find the right starting point.
Let's plan your next visit.
Visit GRIYO
Open late, because life happens.
Evening and Saturday hours make it easier to fit care into your week.
Address8223 Fredericksburg Rd, Suite 102
San Antonio, TX 78229
San Antonio, TX 78229
Phone(210) 993-3689
Hours of OperationMon–Fri 9 AM–9 PM
Sat 9 AM–2 PM
Sat 9 AM–2 PM
Patient Portal & Bill Pay
Current patients can log in to the secure Athenahealth portal. Bill pay is available after login or as a guest.
Open Patient Portal- Acute Bronchitis
- Anxiety & Depression
- Arthritis & Joint Pain
- Asthma & COPD (Lung Health)
- Atrial Fibrillation (AFib)
- Constipation
- Coronary Artery Disease
- Dementia
- Diabetes & Prediabetes
- Dizziness
- Enlarged Prostate (BPH)
- Fatty Liver Disease
- Fibromyalgia
- GERD (Acid Reflux)
- Gout
- Heart Failure
- High Blood Pressure (Hypertension)
- High Cholesterol
- Irritable Bowel Syndrome (IBS)
- Migraine
- Obstructive Sleep Apnea (OSA)
- Osteoporosis
- Peripheral Artery Disease (PAD)
- Pneumonia
- Post-Stroke Care
- Preventive Care (Annual Wellness)
- Psoriasis
- Thyroid Disorders
- Urinary Tract Infection (UTI)
- Weight Management & Obesity
Have a question about a condition or symptom?
Call the office and we’ll help you decide on the right next step.
Call the office to make your appointment
Dr. Pierre M. Agnant, MD, MPH, MBA, MAcc
At GRIYO Primary Care, Dr. Pierre M. Agnant brings a wealth of expertise and a heart for service to the San Antonio community. A board-certified Internal Medicine specialist, Dr. Agnant earned his credentials at the University of Texas Rio Grande Valley and has spent almost a decade as a Hospitalist, serving diverse communities across five states. This extensive experience in complex medical environments has shaped his commitment to high-quality, comprehensive care.
Driven by the belief that healthcare should be built on trust and familiarity, Dr. Agnant founded GRIYO with his wife, Dr. Lise V. Agnant Malebranche. From preventative wellness to advanced medical treatments, he prioritizes professionalism and integrity, treating every patient with the same care he would his own family. Whether you are visiting for a routine check-up or seeking advanced treatment, Dr. Agnant offers a compassionate, multilingual approach, speaking English, Spanish, French, and Haitian Creole. He looks forward to welcoming you to your new medical home.
Dr. Lise V. Agnant Malebranche, MD, MPH, MBA
For Dr. Lise V. Agnant Malebranche, healthcare is about more than just treating symptoms; it’s about building a foundation for a healthier life. A board-certified Internal Medicine physician, Dr. Malebranche transitioned into primary care after almost a decade of serving as a Hospitalist in various Texas communities. Her deep experience in hospital settings gives her an expert edge in navigating advanced treatments and complex diagnoses.
Dr. Malebranche co-founded GRIYO Primary Care to bring that high-level expertise back to the neighborhood clinic. She believes in a “whole-person” approach, blending her clinical training from the University of Texas Rio Grande Valley with the warmth and familiarity that the name GRIYO represents.
Whether she is managing chronic conditions or focusing on preventative wellness, Dr. Malebranche prioritizes integrity and accessibility. She is proud to offer care in English, French, and Haitian Creole, ensuring that her patients in San Antonio feel comfortable and fully supported in their health journey.